GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs728616 | 1 | rs56317427 | chr10:81861934 | TSPAN14 | chr10:82214038-82282390:+ | 0.22 | 3.49 | 0.000537 | Chronic obstructive pulmonary disease-related biomarkers |
| THCA | cis | rs60843830 | 1 | rs56321614 | chr2:268191 | SH3YL1 | chr2:218138-264810:- | -0.93 | -25.71 | 3.43E-92 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs2129782 | 1 | rs56324438 | chr8:89440456 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.32 | 1.57E-7 | Electrodermal activity |
| THCA | cis | rs73086581 | 1 | rs56324992 | chr20:3978153 | MAVS | chr20:3827449-3856761:+ | -0.25 | -3.94 | 9.33E-5 | Response to antidepressants in depression |
| THCA | cis | rs2241437 | 1 | rs56326127 | chr2:86212201 | POLR1A | chr2:86253453-86333278:- | -0.27 | -3.68 | 0.000256 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs73201462 | 1 | rs56328893 | chr3:128041830 | EEFSEC | chr3:127872313-128127488:+ | -0.22 | -3.76 | 0.000188 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs237743 | 1 | rs56335217 | chr20:47871197 | DDX27 | chr20:47835832-47860612:+ | 0.27 | 4.9 | 1.33E-6 | Height |
| THCA | cis | rs2455601 | 1 | rs56336128 | chr11:8908299 | TMEM9B | chr11:8968840-8986481:- | -0.24 | -4.47 | 9.9E-6 | Schizophrenia |
| THCA | cis | rs4785204 | 1 | rs56337141 | chr16:50092690 | HEATR3 | chr16:50099881-50139373:+ | -0.4 | -6.21 | 1.16E-9 | Esophageal cancer (squamous cell) |
| THCA | cis | rs6504950 | 1 | rs56348638 | chr17:53064550 | STXBP4 | chr17:53046126-53241449:+ | -0.15 | -4.18 | 3.4E-5 | Breast cancer |
| THCA | cis | rs6504950 | 1 | rs56348638 | chr17:53064550 | TOM1L1 | chr17:52978052-53039328:+ | -0.13 | -3.37 | 0.000824 | Breast cancer |
| THCA | cis | rs16895812 | 1 | rs56352995 | chr6:42500457 | PRPH2 | chr6:42664334-42690358:- | -0.29 | -3.85 | 0.000135 | Obesity-related traits |
| THCA | cis | rs3771570 | 1 | rs56363214 | chr2:242227157 | ANO7 | chr2:242127924-242164791:+ | 0.36 | 4.22 | 2.97E-5 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs56363214 | chr2:242227157 | SEPT2 | chr2:242254723-242293439:+ | -0.29 | -4.3 | 2.06E-5 | Prostate cancer |
| THCA | cis | rs867186 | 1 | rs56363533 | chr20:33626005 | PROCR | chr20:33758727-33765164:+ | -0.34 | -5.57 | 4.16E-8 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |